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KMID : 0357920050390020114
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Korean Journal of Pathology
2005 Volume.39 No. 2 p.114 ~ p.119
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Prognostic Significance of Abnormal β-catenin Expression in Breast Carcinoma
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Lee Won-Ae
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Abstract
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Background: The subcellular localization and activity of β-catenin are tightly regulated within the cell. The aim of this study was to analyze the aberrant β-catenin expression in breast carcinomas and to determine its clinical significance.
Methods: Fifty five cases of breast carcinoma were immunostained with monoclonal antibodies against β-catenin. Normal expression of β-catenin was defined as exclusive membranous staining. Abnormal expression of β-catenin was reclassified into 3 categories: complete or partial loss of membranous staining (LOM) without cytoplasmic staining and nuclear staining, LOM with cytoplasmic staining and without nuclear staining, and LOM with nuclear staining and with/without cytoplasmic staining.
Results: Normal membranous β-catenin expression was detected in 25 (45.5%) of 55 cases of breast carcinoma. Thirty cases with abnormal β-catenin expression comprised 9 cases (16.1%) showing LOM without cytoplasmic and/or nuclear staining, 20 cases (36.4%) showing LOM with cytoplasmic staining and without nuclear staining, and one case (1.8%) showing LOM with nuclear and cytoplasmic staining. Abnormal β-catenin expression was significantly correlated with lymph node metastasis (p=0.03). LOM with cytoplasmic and/or nuclear expression was significantly correlated with poor disease free survival by univariate (p=0.03) and multivariate analyses (p=0.03). In addition, it was correlated with poor overall survival with a borderline significance (p=0.059).
Conclusions: This study suggests that the cytoplasmic and/or nuclear expression of β-catenin can be used as a biologic marker for predicting disease recurrence and poor patients´ survival in breast carcinomas.
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KEYWORD
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Beta catenin, Immunohistochemistry, Survival, Carcinoma, ductal, breast
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